Conception and Evaluation of Biodegradable Implant Rod for Drug Delivery

Abstract

Polymer implants are an exciting new development in the field of drug delivery systems. Because of their surface and bulk qualities, biodegradable polymers are often used. In the current investigation, a biodegradable implant in the form of a rod was manufactured by the use of a hot melt extrusion process, with PLGA and ethyl acetate serving as the plasticizer. Research was studied on the PLGA/EA rods' deterioration in vitro. At various time intervals, the rods' weight reductions were measured and studied. The techniques of DSC, TGA, and FTIR were used in order to characterize the rods. In order to determine the rod's capability for encapsulating drugs, a drug was first integrated into the rod. The amount of drug in rodents was determined by the use of the UV spectrophotometer method.